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Chemicals company Dow says 291 jobs are at risk at its Barry site as it plans to close its basics siloxanes plant.
Dow said the "potential outcome" was the result of "an assessment of its European assets," and the jobs would go over the next three to four years.
Siloxanes are chemical compounds made of silicone and oxygen and are the building blocks of the silicones found in sealants and adhesives.
Other areas of the operation in the Vale of Glamorgan factory will be unaffected but the union representing workers has criticised the proposals.